Hidde ploegh biography

He returned to Europe inand after having held positions in Germany and the Netherlands he joined the faculty of MIT as full professor in In he became the incumbent of the Mallinckrodt Professorship in Immunopathology at Harvard Medical School and taught both undergraduate and graduate immunology as the director of the graduate program in immunology.

He was recruited back to MIT in His earlier work centered on the analysis of the biochemical pathways involved in antigen processing and presentation by the products of the Major Histocompatibility Complex MHCwhich led to studies into glycoprotein biosynthesis and trafficking more generally. The discovery that human cytomegalovirus exploits an unusual mechanism to dispose of Class I MHC products, critical for recognition by cytotoxic T cells of virus-infected cells, led to observations that illuminated new aspects of glycoprotein quality control.

Archived from the original on 24 July In Pernis, Benvenuto ed. Cell Biology of the Major Histocompatibility Complex. Academic Press. ISBN Nov 21, Bibcode : Natur.

Hidde ploegh biography

Voice of America. Retrieved December 14, New Scientist. May 30, Proceedings of the National Academy of Sciences. Bibcode : PNAS. Authority control databases. Hidden category: Articles with hCards. Toggle the table of contents. Hidde Ploegh Hidde Ploegh's laboratory is interested in the biochemistry of immune recognition, and in mechanisms by which pathogens avoid being seen by the immune system.

His earlier work centered on the analysis of the biochemical pathways involved in antigen processing and presentation by the products of the Major Histocompatibility Complex MHCwhich led to studies into glycoprotein biosynthesis and trafficking more generally. The discovery that human cytomegalovirus exploits an unusual mechanism to dispose of Class I MHC products, critical for recognition by cytotoxic T cells of virus-infected cells, led to observations that illuminated new aspects of glycoprotein quality control.

Ploegh has applied chemistry to develop activity-based probes to study proteasomal proteolysis and more specifically the role of ubiquitin-specific proteases, also in the context of herpesvirus infections. More recently Ploegh has combined the generation of camelid-derived antibody fragments with a protein engineering approach, based on the use of bacterial sortases in conjunction with peptide chemistry.

This combination is being developed to enable the visualization, by non-invasive means, of anti-tumor and anti-virus immune responses using positron emission tomography.